• Guidy@lemmy.world
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    11 hours ago

    Hopefully it’s not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

    That’d be… neat.

  • surfrock66@lemmy.world
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    20 hours ago

    There’s a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn’t so psychoactively impacting. You don’t get sedated, the addiction profile is way less, and the LD50 means OD’ing is much harder. I’m sure there’s dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

    https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

    • surewhynotlem@lemmy.world
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      20 hours ago

      For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

    • Kyrgizion@lemmy.world
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      20 hours ago

      allowing people impacted by chronic pain to re-enter the work force

      You mean they’re just going to force utterly crippled and suffering people to work instead of taking some time to heal in a hospital…

      • surfrock66@lemmy.world
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        20 hours ago

        No, lots of people out there years out from an accident or injury can’t work and it leads to the opioid addiction cycle; having an option to control the pain and get people able to either work or do hobbies again, or do things with their families, would be huge.

      • don@lemm.ee
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        20 hours ago

        Nowhere in their comment did they even come close to implying what you’re suggesting. There are many folk who’d love to go back to doing the things they love, which includes actual work, but can’t, because the hospital did all they could and sent them on their way to deal with crippling pain on their own. This might let those people go back to doing what they love to do.

        Stop making shit up.

      • catloaf@lemm.ee
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        19 hours ago

        There are multiple conditions that cause pain for no apparent physiological reason.

  • Trimatrix@lemmy.world
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    21 hours ago

    I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

      • TheTechnician27@lemmy.world
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        19 hours ago

        Alternative: send Vertex Pharmaceuticals’ board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

        • huppakee@lemm.ee
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          17 hours ago

          Yes that will get people to do research and make new meds available. /s

          • TheTechnician27@lemmy.world
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            16 hours ago

            Should I have added “nationalize it and make future research funded and owned by the public”? (A lot of public funding already goes to medical research, but the profits get privatized.)

            Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn’t the only way to do medical research.

            • huppakee@lemm.ee
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              15 hours ago

              The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I’m not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

    • Mouselemming@sh.itjust.works
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      20 hours ago

      I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

  • Gina@lemmy.wtf
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    21 hours ago

    significantly more favorable side effect profile

    So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

    • 11111one11111@lemmy.world
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      20 hours ago

      It does but they didnt explain. It’s the reduced impact on a person’s brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

      Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

    • don@lemm.ee
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      20 hours ago

      There’s this at the bottom of the article. It may have what you’re looking for.

    • DavidGarcia@feddit.nl
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      21 hours ago

      I’ll only make your dick fall off (and grow one first if you don’t have one)

  • altphoto@lemmy.today
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    13 hours ago

    Its great! And if you pop the miniature eyes that grow behind your ear in the first month, you don’t have to get them surgically removed! A lot of people might think “hmm extra eyes! Heck yeah!” But what they don’t get is how weird everything looks from behind. And the blinking! Nobody wants to be behind you and watch you blink. But you just pop them first sight and you’ll be happy as a clown!.. Clam! Sorry!